S100A4 (also named as calvasculin, mts-1, pEL-98, 18A2, p9Ka, CAPL, Fspl, etc.), a member of the S100 protein family, was defined to be engaged in tumor invasion and metastasis [8], but not oncogenesis per se as S100A4 transgenic mice do not develop tumor. This evidence concerns the gene S100A4 and neoplasm.