MUC5AC and infection: The function of the CCHFV mucin-like domain is presently not known but in Ebola virus a mucin-like domain in virion glycoprotein GP1 has been shown to be involved in multiple functions during infection and may have an important role in pathogenesis.53–55 Virion glycoprotein Gc of herpes simplex virus also contains a mucin-like domain that appears to be involved in cell entry and release of virus from infected cells.56 The influence of genogroup-associated variations in the length and extent of O-glycosylation in the mucin-like domain of various nairoviruses requires further study.