The expression of other NKG2D ligands is likely to be regulated by histone acetylation as well; however, the fact that the increased susceptibility of MCC cells after inhibition of histone acetylation to LAK cell mediated cytotoxicity is abrogated by an MICA/B blocking antibody strongly argues that induced MICA and MICB expression is the dominating effect. Here, MICB is linked to Merkel cell skin cancer.