MET and neoplasm: miR-34a regulates a variety of target mRNAs such as Notch, hepatocyte growth factor receptor (MET), the proto-oncoproteins MYC and MYCN, various cyclins and CDKs, leading to tumor suppression effects such as cell proliferation inhibition, migration and invasion inhibition, cell cycle arrest and apoptosis11, 12, 13, 14, 15, 16, 17.