However, the hypomethylation occurred in the gene body of ANO1, whereas in S100A11 it was the promoter that was hypomethylated, and the expression level of ANO1 in these HCC cells is suppressed, whereas the expression of S100A11 is elevated in subpopulation I (Figure 6A and 6B). The gene discussed is S100A11; the disease is hepatocellular carcinoma.