To further test the relationship between AD and ApoER2 alternative splicing, we analyzed ApoER2 RNA from the hippocampus of young (1–2 months) and aged (3–7 months old) mice that harbor the human APP695 cDNA transgene with the Swedish (K670N, M671L) and Indiana (V717F) mutations (TGCRND8; Chishti et al, 2001). The gene discussed is LRP8; the disease is Alzheimer disease.