For example, a decrease in Reelin has been shown to be associated with amyloid accumulation, and Reelin overexpression in mice has been shown to improve cognition in mouse models of AD (Chin et al, 2007; Kocherhans et al, 2010; Herring et al, 2012; Cuchillo‐Ibanez et al, 2013; Krstic et al, 2013; Pujadas et al, 2014). The gene discussed is RELN; the disease is Alzheimer disease.