Although the mechanism by which ApoE modifies AD risk is not entirely clear, there are apoE isoform‐specific effects on synaptic plasticity, cell signaling, lipid transport, and neuroinflammation as well as on amyloid‐β (Aβ) peptide aggregation and clearance in the brain (Kanekiyo et al, 2014; Kim et al, 2014). The gene discussed is APOE; the disease is Alzheimer disease.