To test whether changes in ApoER2 exon 19 splicing are associated with cognitive impairment, samples of the middle temporal region of brains from participants of age 70 years and older in the Religious Orders Study who died with no cognitive impairment (NCI), mild cognitive impairment (MCI), or AD were obtained from the Rush Alzheimer's Disease Center (Table 1). Here, LRP8 is linked to early-onset autosomal dominant Alzheimer disease.