To evaluate whether the increase in ApoER2 exon 19 inclusion that is induced by ASO‐21 treatment could affect synaptic transmission in AD mice, we used field potential electrophysiological recordings to measure synaptic strength and plasticity in the hippocampal Schaffer collateral—CA1 pyramidal neuron pathway of 20‐week‐old TgCRND8 AD and WT mice. The gene discussed is LRP8; the disease is Alzheimer disease.