LRP8 and Alzheimer disease: This Reelin‐mediated protection against Aβ‐toxicity is selectively impaired by ApoE4, the most prevalent risk factor for late‐onset Alzheimer's disease (Strittmatter & Roses, 1996), which sequesters Apoer2, as well as glutamate receptors that are associated with it, in the recycling endosome.