At the same time within each tumor type the KRAS driver substitution that was identified as being favored only in that tumor type (c.34G > T for LUAD, and c.34G > C for PAAD) showed a significant association with tumor stage (P = 0.01 and 0.03, for LUAD and PAAD respectively, Fig. 4). This evidence concerns the gene KRAS and pancreatic adenocarcinoma.