Immunohistochemistry of the three most regulated genes according to Table 2 confirmed strong overrepresentation of neuronal pentraxin-2 (NPTX2) and carbonic anhydrase 9 (CA9) as well as the underrepresentation of uromodulin (UMOD) in ccRCC [14–16]. This evidence concerns the gene UMOD and nonpapillary renal cell carcinoma.