RUNX1 and leukemia: Indeed, RUNX1 gene is involved in multiple leukemia associated chromosomal translocations (8;21) RUNX1-ETO, (16;21) RUNX1-MTG16, (3;21) RUNX1-Evi1, (12;21) TEL-RUNX1, and (X;21) RUNX1-FOG2 [20, 21].