El-Assal ON et al. [44] used an invasiveness score based on 6 pathological parameters, Roayaie S et al. [45] used a system of microvascular invasion, Pan QX et al. [46] used the Glasgow Prognostic Score based on C-reactive protein and albumin level, Yamamura K et al. [47] used the neutrophil to lymphocyte ratio (NLR) prognostic score, Zhao WH et al. [48] used the pre-surgery Cancer of the Liver Italian Program (CLIP) score and Shim JH et al. [49] used the preoperative AFP<20ng/mL to predict HCC recurrence. The gene discussed is CRP; the disease is hepatocellular carcinoma.