TERT and urinary bladder cancer: Although TERT and FGFR3 are remarkably good biomarkers for UBC due to high prevalence and the focussing of point mutations at hotspots, the mutations in other genes commonly mutated in bladder cancer are not clustered in such a manner [18], and are therefore more challenging to detect—much more DNA has to be sequenced such that PCR and sequencing errors, and non-bladder cancer specific alterations, may give false positive results.