MAPK8 and cancer: Different mechanisms have been suggested for its anti-cancer activity depending on the cancer models evaluated (breast, colon, leukaemia, hepatic, melanoma) [7] including the inhibition of matrix metalloproteinases (protease enzymes involved in invasion and metastasis processes) [57]; PI3/Akt and MAPK signalling pathways [56]; cell cycle arrest at G2/M [58]; and induction of apoptosis via ROS/JNK-mediated mitochondrial/caspase pathway [59].