As shown in Figure 2a, the mRNA expression of Krt6, Krt14, and Krt16 which are associated with hyper-proliferation of keratinocytes, and of antimicrobial peptide S100a8, which is correlated with psoriasis severity, were significantly increased by imiquimod treatment in the vehicle (PBS)-injected group. The gene discussed is KRT72; the disease is psoriasis.