LRP6 and hereditary cancer: We analyzed the frequency of the potentially pathogenic variants that we identified in the EMR3, PTPN12 and LRP6 genes in an additional cohort of locally sequenced control individuals without any suspicion for hereditary cancer, and in data from the Exome Aggregation Consortium.[33] The local control individuals were sequenced at a high coverage and exhibited sufficient read depth for our three candidate genes (Control dataset 2; n = 2,329; S2 Fig and Materials and Methods for a detailed description).