LRP6 is a core-component of the WNT-FZD-LRP5-LRP6 receptor complex of the WNT signaling cascade, which is commonly activated in colon cancer.[42] Previously, this gene was also identified in a screen for mouse CRC susceptibility loci.[30] Remarkably, we found that the rare LRP6 variants were present in three of the youngest diagnosed individuals in our cohorts (age 23, 24 and 29). This evidence concerns the gene LRP6 and colorectal carcinoma.