All variants were located in β-propeller domains (Fig 3A and 3B), which are involved in the binding of WNT ligands and antagonists, such as WNT3a and Dickkopf-1, respectively.[31] Data from ‘The Human Protein Atlas’ revealed that LRP6 is expressed at high levels in colonic tissue.[22] Interestingly, LRP6 has also been found to be affected by somatic mutations in colorectal adenocarcinomas,[24] in which most of these mutations appear to occur within in the β-propeller domains (Fig 3A), thus supporting a role of missense variants in this gene in CRC development. This evidence concerns the gene WNT3A and colorectal carcinoma.