Our findings are in line with a polygenic model of CRC susceptibility in which multiple risk factors in known and novel CRC pathways may contribute to additive risks.[54] Future studies, such as functional assessments of the candidate genes and replications in larger CRC and control cohorts, are needed to firmly establish the role of PTPN12 and LRP6 in CRC susceptibility. This evidence concerns the gene LRP6 and colorectal carcinoma.