One of the candidate genes, PTPN12, encodes the widely expressed cytoplasmic protein tyrosine phosphatase PTP-PEST, which regulates epithelial cell adhesion and migration.[25,39–41] In colon carcinoma cells, PTP-PEST has been shown to control cell motility and adherence junction assembly by regulating the intracellular localization of p120 catenin and, consequently, its interaction with E-cadherin.[27] Therefore, PTP-PEST may play a role in the tightly controlled migration of epithelial cells of the colonic crypts. The gene discussed is CTNND1; the disease is colon carcinoma.