ATM and colorectal carcinoma: Somatic nonsense mutations in ATM occur frequently in CRC, but monoallelic germline mutations have thus far only been shown to increase the risk for gastric, breast and pancreatic cancers, and mostly when they result in truncated proteins.[18–20] Potentially pathogenic missense variants in ATM were also found twice in a cohort of 164 healthy individuals (Control dataset 1; see Materials and Methods and below) and we, therefore, conclude that ATM is not enriched in our cohort of CRC cases.