LRP5 and colonic neoplasm: LRP6 is a core-component of the WNT-FZD-LRP5-LRP6 receptor complex of the WNT signaling cascade, which is commonly activated in colon cancer.[42] Previously, this gene was also identified in a screen for mouse CRC susceptibility loci.[30] Remarkably, we found that the rare LRP6 variants were present in three of the youngest diagnosed individuals in our cohorts (age 23, 24 and 29).