EMR3 belongs to the EGF-TM7 protein family of G-protein coupled receptors and is specifically expressed in granulocytes and data from ‘The Human Protein Atlas’ suggest that EMR3 is not or only very lowly expressed in colonic tissue.[21,22] EMR3 has been suggested to function as a mediator of invasive phenotypic variation in glioblastoma.[23]. This evidence concerns the gene ADGRE3 and glioblastoma.