HLA-DRB1*04 (p = 0.0143; OR = 1.92; 95% CI = 1.14 to 3.23) showed strong interaction with alcohol (p< 0.0001; OR = 8.43; 95% CI = 3.85 to 18.5) and increased the significant risk for development of pulmonary TB when compared to non-carriers of the allele. This evidence concerns the gene HLA-DRB1 and pulmonary tuberculosis.