Stepwise logistic regression analysis on the effect of interaction of alcohol and HLA alleles on bacterial load (multibacillary and paucibacillary) showed that carriers of HLA-DRB1*04:11:01 (p = 0.0442; OR = 2.01; 95% CI = 1.03 to 3.93) or HLA-DRB1*04:92 (p = 0.0112; OR = 8.62; 95% CI = 1.63 to 45.5) who consume alcohol (p = 0.0026; OR = 11.1; 95% CI = 3.99 to 30.9) have higher risk of developing multibacillary pulmonary TB. The gene discussed is HLA-DRB1; the disease is pulmonary tuberculosis.