Only the interaction of alcohol (p = 0.0001; OR = 51.3; 95% CI = 6.81 to 386) with HLA-DRB1*04:11:01(p = 0.0265; OR = 2.13; 95% CI = 1.09 to 4.14) showed a very high risk of susceptibility to pulmonary TB. The gene discussed is HLA-DRB1; the disease is pulmonary tuberculosis.