Furthermore, good interaction between HLA/peptide have a crucial role for the development of a Th1 effector response against pathogen [56].Our data suggest that carriers of HLA-DRB1*04:07:01 may have a good T cell response against TB bacillus while carriers of HLA-DRB1*04:11:01 may have a poor immune response effector. The gene discussed is HLA-DRB1; the disease is tuberculosis.