Despite that IL-1 itself promotes anorexia23 using IL-1 receptor antagonist was not sufficient to impair cachexia progression in a rat model.24 Nevertheless, human polymorphisms in IL-1B gene, resulting in augmented levels of IL-1β, were associated with a negative prognostic value,25 indicating the involvement of IL-1 pro-inflammatory cytokines in the pathogenesis of cachexia. The gene discussed is IL1A; the disease is Cachexia.