IL6 and Cachexia: Although liver contributes to cachexia by increasing energy expenditure through gluconeogenesis and reducing very low-density lipoprotein circulation, it participates as well to the worsening of inflammation by secreting acute phase proteins and reducing albumin secretion, a process mostly driven by IL-6 and TNFα.107, 108 This eventually results in muscular protein breakdown and adipocytes lipolysis.27