Decreased insulin sensitivity during tumor progression has also been reported in drosophila,54, 55 and in mice,39 where Colon-26 tumor inoculation was sufficient to induce insulin resistance before cachexia onset,39 while in Walker 256 tumor-bearing rats isolated Langerhans islet were more resistant to glucose challenge, resulting in decreased insulin secretion.153. The gene discussed is INS; the disease is Cachexia.