The work from Waning et al.51 showed that, in several mouse models of bone metastasis, increased transforming growth factor beta signaling (released during osteolysis caused by bone metastasis) promotes skeletal muscle oxidation of the calcium channel RyR1 (ryanodine receptor and calcium release channel), ultimately leading to leaky channels and inefficient muscle activity. Here, RYR1 is linked to bone metastasis.