IL4 and Cachexia: Other members of the IL-6 family such as ciliary neurotrophic factor and leukemia inhibitory factor have also been associated with cachexia development.30, 31 The upregulation of pro-inflammatory cytokines co-occurs with decreased expression of the cytokines hampering inflammation, such as IL-4 -10 and -12.32 Coherently, several treatments controlling excessive inflammation provided beneficial effects on cachexia progression.32, 33, 34, 35