Albeit not as penetrant as skeletal muscle wasting, adipose tissue depletion has been identified as one of the symptoms of cachexia.114, 115 Indeed, cachectic patients manifest high levels of circulating free fatty acids, glycerol and triacylglycerol.116, 117 This is linked to the increased circulation of several factors promoting lipid mobilization, such as the adipokine Zn-alpha 2-glycoprotein/lipid-mobilizing factor (ZAG/LMF), IL-1, IL-6 and TNFα.15, 16, 32. The gene discussed is TNF; the disease is Cachexia.