KRAS and pancreatic neoplasm: Coherently, in a K-RAS-driven transgenic model of pancreatic cancer the increase in circulating amino acid was present before the actual tumor was detectable.181 This effect on the host, even at early phase of tumor growth, when no evidence of discomfort is present, indicates the importance of actively understanding the interplay between tumor and the host on a systemic level, with a particular focus toward the metabolic dependencies of growing tumors.