We and others have previously shown that TBX3 promotes migration of breast and bladder carcinomas and melanoma cells by a process involving its ability to repress the cell adhesion molecule, E-cadherin.20, 23, 24, 35 Here we show that TBX3 similarly impacts on migration of chondrosarcoma, liposarcoma and rhabdomyosarcoma cells, but they did not however express detectable levels of E-cadherin (data not shown). This evidence concerns the gene CDH1 and liposarcoma.