In the present study, we screened a panel of sarcoma cell lines and patient-derived tissue and show that TBX3 is highly expressed in sarcomas representative of diverse histological subtypes and that, similar to its role in carcinomas, it promotes migration of chondrosarcoma, liposarcoma and rhabdomyosarcoma cells. The gene discussed is TBX3; the disease is rhabdomyosarcoma.