TBX3 and neoplasm: To further explore the putative tumour suppressor activity of TBX3 in fibrosarcomas, we characterized the impact of stably knocking down TBX3 in CT-1 and HT1080 fibroblasts (Figure 6a) or overexpressing the Tbx3 and Tbx3+2a isoforms in the HT1080 cells (Figure 6b) on key features of the cancer phenotype.