There is a significant body of evidence implicating TBX3 as an oncoprotein in several carcinomas; however, nothing is known about its status and role in sarcomas.12, 13, 24, 25, 26, 27, 28, 29 Here we show that TBX3 is highly expressed in a panel of soft tissue and bone sarcoma cell lines and patient-derived sarcoma tissue. The gene discussed is TBX3; the disease is bone sarcoma.