TBX3 and chondrosarcoma: To determine the effect of TBX3 on chondrosarcoma cell proliferation, growth curve analyses and 5-bromo-2-deoxyuridine (BrdU) incorporation assays were performed and results showed that compared with their control cells, ATDC5 and SW1353 shTBX3 chondrosarcoma cells exhibited a significantly slower growth rate under normal and reduced serum conditions (Figures 3c and d).