DEGs involving in virus infection were observed in the PPI network including CREB3L1, FDPS and IRS2 (Table 3), in which CREB3L1 was reported to be associated with iCell hepatocyte (induced pluripotent stem cell derived hepatocytes from Cellular Dynamics International) susceptibility to HBV infection [19]. The gene discussed is CREB3L1; the disease is viral infectious disease.