Moreover, Lp(a) prothrombotic effect might also be related to the similarity of apo(a) to plasminogen, thereby interfering with plasminogen’s antithrombotic functions [5,6,7] Several studies, including a large meta-analysis, demonstrated that high circulating Lp(a) levels were consistently associated with coronary artery disease (CAD) [8–11], and represent an independent predictor of coronary artery calcification, as a marker of coronary atherosclerosis [12]. This evidence concerns the gene PLG and coronary artery disorder.