The ESLA-7 signature includes genes ADAM10 and FGFR10P, which have been reported to contribute to oncogenesis of various cancer types including lung cancer, and whose function indicates that they may take part in oncogenic transformation and/or increase cell proliferation by interaction with major signaling cascades (ERK1/2, p38 MAPK, and STAT, Notch1, RAS/MAPK, PLC-γ, and PI3K/AKT). The gene discussed is NOTCH1; the disease is cancer.