As one example, the HDAC6 inhibitor tubastatin A reduced levels of pro-inflammatory mediators and also promoted bacterial clearance, and thus survival, in a murine cecal ligation puncture models of sepsis.103 A pharmacological agent with the capacity to simultaneously suppress pathological inflammatory responses and boost host defense pathways may be considered as the holy grail of drug discovery in innate immunity research. Here, HDAC6 is linked to Sepsis.