CD4 and colitis: In the TNBS colitis model, oral administration of GC led to an increased peripheral/intrahepatic CD4/CD8 lymphocyte ratio, decreased STAT-1 and -4 expression, and overexpression of STAT-6, along with decreased IFN-γ serum levels.44 The effects on the systemic immune system were associated with the alleviation of colitis manifested by improvement of both the macroscopic and microscopic scores.