GP2 and Cowden disease: There are no goblet cells in the dome epithelium, and M cells have a scarce glycocalyx allowing easy microbial interaction.27 Peyer's patches are sites of lesions in Crohn's disease (CD), and the 'anti-pancreatic' antibody associated with CD is targeting glycoprotein 2, the receptor for type 1 bacterial fimbrial protein (fimH) on M cells.