FN1 and cancer: Plasma and cellular Fn mediate different biological behaviors; plasma Fn is essential in clots during early wound healing, whereas cellular Fn mediates late wound healing, neovascularization, and angiogenesis (Fig. 1a).50,147 Fn is also implicated in other physiological (e.g., embryogenesis156) and pathological30 (e.g., fibrosis, cancer) processes.