Within the down-regulated signaling pathways, there were ubiquitin-mediated proteolysis, mTOR signaling, pathways in cancer, RIG-like receptor signaling pathway with Herc1 and Traf6, Mapk1 and Rps6ka3, Ifg1r, Prkx, and Foxo1 as the core regulatory factors (Table 4). The gene discussed is HERC1; the disease is cancer.