By gene-act-network analysis and/or co-expression network analysis, some of the signaling pathways shared key regulatory genes, for example, MAPK for focal adhesion, NOD-like receptor, mTOR, pathway in cancer signaling pathways, and transcriptional factor Jun for focal adhesion and pathways in cancer, STAT5 for JAK-STAT and chemokine signaling pathways. This evidence concerns the gene JUN and cancer.