RASSF1A, a member of the RASSF1 family, is a downstream regulator of Hippo, there are approximately 50 % of ovarian tumors harbor hypermethylation of RASSF1 [52], investigations shown that overexpression of RASSFIA could increase stabilization of microtubules then restore PTX sensitivity [53]. Here, RASSF1 is linked to ovarian neoplasm.