Low protein expression of LZTS1 showed little response in patients who received PTX-based chemotherapy in ovarian carcinoma and breast cancer patients, it was a worse prognosis patients outcome [59, 60], previous study by generating LZTS1 knockout mice, detected accelerate mitotic progression resistance to PTX-induced M phase arrest by decreasing CDK1 activity [61], indicated cell cycle distribution may be involved in the above two human cancer. This evidence concerns the gene LZTS1 and breast carcinoma.