The correlation between suprabasin expression and the clinicopathological characteristics of ESCC was explored and showed a positive correlation between suprabasin expression and tumor clinical stage (P < 0.001), T classification (P < 0.001), N classification (P < 0.001), M classification (P = 0.016), and pathological differentiation (P < 0.001) (Fig. 2c,d and Supplementary Table 2). This evidence concerns the gene SBSN and esophageal squamous cell carcinoma.