HBE1 and hepatitis B virus infection: Looking at the different phases of chronic Hepatitis B infection, one could either group these particular patients under chronic immunotolerant phase (HBeAg positive, high HBV viral load and normal liver aminotransferase levels) or chronic immune active wild type HBV infection (HBsAg positive longer than 6 months, HBeAg positive, anti-HBe negative, high HBV viral load, elevated or normal liver aminotransferase levels).