Deletion of the GAT domain (ΔGAT mutant) abolished TOM1L1 pro-invasive activity in SKBR3 cells (Fig. 3a,b) and in HCC-1954 cells (another ERBB2+/ER+/TOM1L1− breast cancer cell line) (Supplementary Fig. 2d,e). This evidence concerns the gene ERBB2 and breast carcinoma.