ERBB2-mediated invasion is also strongly coupled to the capacity of tumour cells to induce extracellular matrix (ECM) proteolysis through the activation of urokinase plasminogen activator, lysosomal cathepsins and multi-domain zinc-dependent endopeptidases or matrix metalloproteases (MMPs)10, 11, 12. This evidence concerns the gene ERBB2 and neoplasm.