NFKB1 and colitis: In view of our findings that DSS-induced colitis is relieved in REGγ-deficient mice, with augmented IκBɛ accompanied by reduced NFκB activity in colon epithelial cells, we wondered whether REGγ aggravates DSS-induced colitis mainly through degrading IκBɛ, which otherwise, in REGγ-deficient mice functions to inhibit colitis progression.