Consistent with alleviated colitis in REGγ−/− mice, ELISA analysis of colonic explants revealed less production of pro-inflammatory cytokines and chemokines including KC, MIP2α, CXCL5, IL-1β, IL-6 and TNFα in REGγ−/− mice than in WT counterparts (Fig. 2c). The gene discussed is IL1B; the disease is colitis.