Therefore, we additionally generated iNPCs-overexpressing mutant-active versions of Src (to mimic infiltrative behaviour), EGFR (duplicated and/or mutated in ∼57% of human gliomas)21 and Ras (mutated in ∼1% of human gliomas and a common upstream regulator of both PI3K and MAPK signalling)21. The gene discussed is EGFR; the disease is central nervous system cancer.