Genes for which decreased SOX2 binding was associated with decreased expression in GTICs and p53KD-Ras/EGFR/SrciNPCs compared with WTiNPCs and p53KDiNPCs were MAP2K5/ERK5, whose activities have been associated with tumour development and the acquisition of mesenchymal stem-like properties in cancer cells34, and C10orf67, a susceptibility locus associated with sarcoidosis and Crohn's disease (Fig. 3a). This evidence concerns the gene MAP2K5 and cancer.