ATP1A2 and migraine disorder: Notably, transgenic knock-in (KI) mouse models that express human pathogenic FHM1 (van den Maagdenberg et al. 2004, 2010) or FHM2 (Leo et al. 2011) mutations revealed increased susceptibility for experimentally induced cortical spreading depression (CSD), the electrophysiological correlate of the migraine aura (Lauritzen 1994), which could be directly linked to increased cortical glutamatergic neurotransmission in FHM1 KI mice (Tottene et al. 2009).