A first example would be the QI about the role of follow-up of sUA level when prescribing UALT: “IF a gout patient is given a prescription for a xanthine oxidase inhibitor, THEN a serum urate level should be checked at least once during the first 6 months of continued use, BECAUSE periodic serum urate measurements are required for appropriate dose adjustments of xanthine oxidase inhibitors (escalations or reductions)”. The gene discussed is XDH; the disease is gout.