We observed increased immature myeloid cells in the peripheral blood, and all of the MSI2 overexpressing NHD13 mice eventually succumbed to various lethal myeloid diseases including MPN/MDS or an AML/MDS with a median latency of 228 days (Fig. 3f–h and Supplementary Fig. 3a–g). Here, MSI2 is linked to acute myeloid leukemia.