However, functional and pathway enrichment analysis of total DEPs and DEGs revealed biological traits more closely linked to cancer, such as p53 signaling pathway, cell cycle, keratinocyte differentiation, focal adhesion, adherens junction, pancreatic cancer, endometrial cancer, acute myeloid leukemia, etc. Nevertheless, the top 50 SDN molecules displayed the maximal enriched terms in terms of GO biological processes and KEGG pathways followed by DEGs, and DEPs were only enriched in biological processes of peptide cross-linking and epidermal cell differentiation (Supplementary Table S6). Here, TP53 is linked to cancer.