XBP1 and hepatocellular carcinoma: Duan and colleague45 showed that ER stress downregulated the expression of the miR-199a/miR-214 cluster in HCC cells and further demonstrated that miR-214 could target XBP1 expression via a yet unknown mechanism, suggesting that the miR-199a/miR-214 cluster may represent an example of miRs as both modulators and effectors of the ER stress response.