CD36 combines with a variety of ligands and plays an important role in various physiological and pathological processes, such as the formation of macrophage foam cells, atherosclerosis, angiogenesis, diabetes mellitus, thrombosis, malaria, Alzheimer’s disease, obesity, and tumorigenesis as well, and thus may be a potential target to drug discovery20, 34. This evidence concerns the gene CD36 and early-onset autosomal dominant Alzheimer disease.