SENCR and limb ischemia: In this direction, SENCR is able to inhibit promigratory phenotype of VSMC while stimulating angiogenesis of EC similar to miR-126 which inhibits VSMC migration while restoring EC function in animal models of vascular balloon injury.43 The proangiogenic and promigratory effect induced by SENCR on cultured EC were also correlated in limb ischemia, pathology induced by vascular injury, where SENCR expression was altered.