At the late infection stage, we determined that regulation of MIR101, MIR141, and MIR152 to Gag (p-value < 1☓10-16) results in dysfunction of the infected cells through a signaling cascade of 5 proteins, PRMT1, inositol 1,4,5-trisphosphate receptor type 1 (ITPR1), autocrine motility factor receptor (AMFR), tripartite motif containing 25 (TRIM25), and ubiquitin-conjugating enzyme E2N (UBE2N) (Fig. 7). Here, TRIM25 is linked to infection.