Moreover, we also identified that 5 genes have basal level difference between Hepatocellular Carcinomas (HCCs) and normal cells, including ELAVL1 (P-value < 3.69☓10-5), JMJD1C (P-value < 3.59☓10-11), GADD45A (P-value < 7.32☓10-11), EIF2AK3 (P-value < 5☓10-5), and GSN (P-value < 1.19☓10-2), which is mainly due to DNA methylation of the corresponding genes (Fig. 4). This evidence concerns the gene JMJD1C and hepatocellular carcinoma.