In this study, we identified that the 3 genetic and epigenetic regulations, including the gain of the miRNA regulation of MIR141 to JMJD1C (p-value < 0.789) and the genetic regulation of TP73 to GADD45A (p-value < 0.037) in cancer cells, and DNA methylations of JMJD1C and GADD45A, led to not only changes of gene expression profiles of JMJD1C (p-value < 7.3☓10-11) and GADD45A (p-value < 7.3x☓10-11) but also changes of DNA methylation profiles of JMJD1C (p-value < 0.014) and GADD45A (p-value < 0.096) between human normal liver cells and liver cancer cells (Fig. 4). The gene discussed is GADD45A; the disease is cancer.