After adjustment for demographics, clinical factors, comorbidities, laboratory tests and β-blocker use, NTproBNP continued to have a statistically significant association [HR, 95 % confidence interval (CI)] with SCD [1.27 (1.13–1.43); p < 0.001]] whereas as the association between cTnI and SCD was not statistically significant [1.17 (0.98–1.40); p = 0.08]. The gene discussed is NPPB; the disease is Schnyder corneal dystrophy.