NPPB and cardiovascular disorder: There were no significant interactions in the models for NTproBNP (Fig. 2a) but there was suggestion of effect modification by cTnI and sex (p-interaction =0.02), baseline cardiovascular disease (p-interaction =0.01), serum albumin (p-interaction =0.008), serum potassium (p-interaction = 0.01) and bicarbonate (p-interaction = 0.02).