SERPINE1 and Hepatic fibrosis: One of the isolated constituents from Herba Glechomae longitubae, asiatic acid, inhibits TGF-β1-induced collagen and PAI-1 expression in keloid fibroblasts through PPAR-γ activation [24]; Radix Dioscoreae oppositae attenuats CCl (4)-induced hepatic fibrosis in rats in a dose-dependent manner and the attenuation may be related to the antioxidant properties of Radix Dioscoreae oppositae [25].