The anti-proliferative and pro-apoptotic effects of 5-ASA on several tumor-derived cell lines have been previously reported and different mechanisms have been proposed namely, inhibition of; Wnt/β-catenin pathway [16], EGFR activation [17–19], NF-κB [20], and COX-2 expression [21]. This evidence concerns the gene NFKB1 and neoplasm.