APP and early-onset autosomal dominant Alzheimer disease: MiR-101b regulates the expression of a key protein in Alzheimer ́s disease, the amyloid precursor protein (APP) [77–79], as well as other proteins involved in neurological diseases such ataxin1 [80], and the Autism protein the Fragile X Mental Retardation gene 1 (FMR1) [81], moreover, a key synaptic protein SynGAP1 [82] has been also detected in the hippocampus.