To evaluate the anti-inflammatory and anti-fibrotic effects of CNP in BLM-induced lung fibrosis, we analyzed mRNA expression changes of pro-inflammatory cytokines (IL-1β and IL-6), pro-fibrotic cytokines and proteins (bFGF, TGF-β, TIMP1, and collagen 1A), and GC-B in the lungs. The gene discussed is TIMP1; the disease is pulmonary fibrosis.