PLOD1 and ovarian hyperstimulation syndrome: The increased response to FSH in the presence of p,p′-DDT that we have shown in vitro, and the gain of sensitivity to hCG (and presumably to LH), may therefore be deleterious in vivo. Increased stimulation as a result of EDs may contribute to some cases of unexpected and unexplained spontaneous ovarian hyperstimulation syndrome occurring during controlled ovarian stimulation by gonadotropins in assisted reproduction procedures (Jirsová et al. 2010; Machtinger and Orvieto 2014).