AKT1 and colorectal cancer: Although an effect on p21 transcription was not evaluated, several ZBED6 target genes identified were linked to the Wnt/β-catenin and the phosphatidylinositol-3-kinase (PI3K)/Akt pathways, both of which are not only involved in colorectal cancer development, but also in the control of p21 expression [66, 67].