SP1 and colorectal cancer: Alternatively, by targeting K-Ras [52], as well as B-Raf [70], miR-30 family members also interfere with another tumorigenic pathway (Ras/B-Raf/MEK/ERK) that is implicated in the occurrence of colorectal cancer and that also regulates p21 expression by controlling multiple transcription factors including c-Myc, Mitf and Sp1, as well as members of the forkhead box O (FoxO), Ets, and CCAAT/enhancer-binding-protein (C/EBP) families [71].