Prominent examples are the p53-regulated miR-34 family and the c-Myc-controlled miR-17-92 cluster that exert their tumor suppressive and oncogenic functions via direct translational repression of pro- (e.g. CDK4/6, cyclin D1, cyclin E2, c-Myc) and anti-proliferative (e.g. p21, p57) proteins, respectively [16, 24]. This evidence concerns the gene MYC and neoplasm.