Moreover, data obtained from human tissues indicate that LOX-1 expression correlates with the aggressiveness of the tumor, since it results significantly overexpressed in 72% G1-G2; any T; N0 and in 90% G2-G3; any T; N1,N2,M0,M1 colon cancer, when compared to normal tissue of the same patient. The gene discussed is OLR1; the disease is malignant colon neoplasm.