A GRS was computed with all known and newly identified non‐HLA genetic markers of anti‐CCP–negative RA available in this study (Table 2): ANKRD55, PRL, C5orf30, BLK, STAT4, and NFIA. As expected, the GRS was associated with anti‐CCP–negative RA (OR 2.74 [95% CI 1.92–3.91]) (P = 2.41 × 10−8). This evidence concerns the gene BLK and rheumatoid arthritis.