CDK4 and cancer: Analysis of the MethHC database (a database of DNA methylation and gene expression in Human Cancer http://methhc.mbc.nctu.edu.tw/php/index.php) [37] demonstrated that DNA methylation of FYN, CDK4, MAGED1, ZNF274, BTG3, G0S2 and AP2B1 varies significantly (p < 0.05) between tumor and normal samples, which support our findings since cancer is an aging disease.