VEGFA and central nervous system cancer: However, there was also some question, for example, (1) whether VEGF generate the same results as ESM-1 on HULC silenced cells; (2) whether the effects of ESM-1 be blocked by its antibody such as LFA1; (3) whether there was another effect of hypoxic mimicry with cobalt chloride on glioma biological behavior and what's the effect of HULC silencing on it, which need to further explored.